Scavenger receptors
نویسندگان
چکیده
منابع مشابه
Macrophage scavenger receptors and foam cell formation.
Scavenger receptors bind and internalize modified low-density lipoprotein (LDL) and high-density lipoprotein (HDL). Because the expression of scavenger receptors is not down-regulated by cholesterol, macrophages (Mphi) expressing scavenger receptors can internalize substantial quantities of cholesteryl ester from oxidized LDL and HDL, leading to foam cell formation. Mphi express several differe...
متن کاملScavenger receptors in atherosclerosis: beyond lipid uptake.
Atherosclerotic vascular disease arises as a consequence of the deposition and retention of serum lipoproteins in the artery wall. Macrophages in lesions have been shown to express > or = 6 structurally different scavenger receptors for uptake of modified forms of low-density lipoproteins (LDLs) that promote the cellular accumulation of cholesterol. Because cholesterol-laden macrophage foam cel...
متن کاملScavenger receptors: targets for antiplatelet therapies?
P latelets play a critical role in thrombotic diseases such as myocardial infarction or ischemic stroke. Beyond their role in thrombosis, platelets are the major trigger in boosting atherosclerosis.2 In patients with hypercholesterolemia, platelets are hyperreactive, indicating that circulating lipoproteins in blood influence platelet properties. Lipidlowering drugs result in a reduction of pla...
متن کاملThe Evolution of the Scavenger Receptor Cysteine-Rich Domain of the Class A Scavenger Receptors
The class A scavenger receptor (cA-SR) family is a group of five evolutionarily related innate immune receptors. The cA-SRs are known for their promiscuous ligand binding; as they have been shown to bind bacteria, such as Streptococcus pneumoniae and Escherichia coli, as well as different modified forms of low-density lipoprotein. Three of the five family members possess a scavenger receptor cy...
متن کاملScavenger receptors and heat-shock protein-mediated antigen cross-presentation.
Heat-shock proteins (HSPs) induce protective cytotoxic immune responses against tumour antigens. This property is related to their ability to bind to and to be internalized by DC (dendritic cells) before gaining access to the MHC class I processing pathway, a process called antigen cross-presentation. This process requires internalization of the antigen by DC via endocytic receptors. Owing to t...
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ژورنال
عنوان ژورنال: Current Biology
سال: 2020
ISSN: 0960-9822
DOI: 10.1016/j.cub.2020.05.051